Saranya Ravi

Dr. Saranya Ravi

First Year Resident

Start Year

2024

 

What are your career interests?

General dermatology, skin cancer, hidradenitis suppurativa, cardiovascular risk in dermatological conditions.

 

Why did you choose Duke for residency training? 

When I rotated at Duke as a medical student, I felt supported in my interests. I could see how genuinely excited all the attendings were to teach.  With the cutting edge research and world experts in multiple areas of dermatology, I knew I would get the training necessary for me to feel confident in whatever I pursue in the future.

 

Education & Training 

Undergraduate:  Mount Holyoke, BA, Neuroscience, 2009

Graduate School: University of Alabama at Birmingham, PhD, 2015

Medical School: University of North Carolina at Chapel Hill, MD, 2023 

Internship: Harnett Health, Dunn NC, 2023-2024 

Residency: Dermatology, Duke University, 2024 - 2027

 

Awards & Honors 

  • American Heart Association Post-Doctoral Fellowship, 7/1/2017 – 7/30/2019. “Understanding the effect of the deletion of CXCL5 on atherosclerosis”
  • American Heart Association Pre-Doctoral Fellowship, 7/1/2013 – 6/30/2015. The role of mitochondrial DNA in oxidative stress and bioenergetics function of monocytes and macrophages”
  • First Place Graduate Student Research Day Oral Presentations, University of Alabama at Birmingham, (February 2015)
  • First Place Pathology Trainee Research Day Poster Presentations, University of Alabama at Birmingham, (October 2014)
  • Center for Free Radical Biology, University of Alabama at Birmingham, Travel Award (January 2014)
  • First Place Pathology Trainee Research Day Poster Presentations, University of Alabama at Birmingham, (October 2013)
  • Department of Pathology, University of Alabama at Birmingham, Travel Award (September 2013)
  • Center for Free Radical Biology, University of Alabama at Birmingham, Travel Award (September 2013)
  • Department of Pathology, University of Alabama at Birmingham, Travel Award (September 2012)
  • Center for Free Radical Biology, University of Alabama at Birmingham, Travel Award (September 2012)
  • Summer Undergraduate Research Fellow (SURF), Mayo Clinic, Undergraduate Research Fellowship (Summer 2008)
  • Dean’s List, Mount Holyoke College (2005, 2006, 2007, 2008)
  • Member, Psi Chi, National Honor Society in Psychology (Fall 2007)
  • Sarah Williston Scholar, Mount Holyoke College, Awarded to top 15% of class at end of sophomore year (Fall 2007)
  • Award for Excellence in Biology, Mount Holyoke College (2005-2006)

 

Publications & Presentations 

  • Ravi, S., Miles, J.A., Steele, C., Christiansen, MK., Sayed, CJ. Patient Impressions and Outcomes After Clinic-Based Hidradenitis Suppurativa Surgery. (2021). JAMA Dermatology, 158(2):132-141.
  • Ravi, S., Sayed, C.J. Fibrotic Signaling Pathways of Skin Fibroblasts in Nephrogenic Systemic Fibrosis. (2019). Current Geriatrics Reports, 8:338–345.
  • Ravi, S., Willis, MS., Schisler, JC. “Fibrotic Signaling in Cardiomyopathies.” Fibrosis in Disease An Organ-Based Guide to Disease Pathophysiology and Therapeutic Considerations, edited by Willis, MS., Yates, CC., Schisler, JC, Springer, 2019, 273-317.
  • Shi, C., Rubel, C., Soss, SE., Sanchez-Hodge, R., Zhang, S., Madrigal, SC., Ravi, S., McDonough, H., Page, RC., Chazin, WJ., Patterson, C., Mao, C., Willis, MS., Luo, H., Stevens, DA., Tang, M., Du, P., Wang, Y., Hu, Z., Xu, Y., Schisler, JC. Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16. (2018). PLoS Genetics, 14(9): e1007664.
  • Rangarajan, S., Bone, NB., Zmijewska, AA., Jiang, S., Park, DW., Bernard, K., Locy, ML., Ravi, S., Deshane, J., Mannon, RB., Abraham, E., Darley-Usmar, V., Thannickal, VJ., Zmijewski, JW. Metformin reverses established lung fibrosis in a bleomycin model. (2018). Nature Medicine, 24(8):1121-1127.
  • Redmann, M, Benavides, GA., Wani, WY., Berryhill, TF., Ouyang, X., Johnson, MS., Ravi, S., Mitra, K., Barnes, S., Darley-Usmar, VM., Zhang, J. (2018). Methods for assessing mitochondrial quality control mechanisms and cellular consequences in cell culture. Redox Biol, 17:59-69.
  • Ravi, S., Parry, TL., Willis, MS., Lockyer, P., Patterson, C., Bain, JR., Stevens, RD., Ilkayeva, OR., Newgard, CB., Schisler, JC. Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP. (2018). J Cardiovasc Dev Dis, 5(3):43.
  • Ravi, S., Schuck, RN., Hilliard, E., Lee, CR., Dai, X., Lenhart, K., Willis, MS., Jensen, BC., Stouffer, GA., Patterson, C., Schisler, JC. Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease. (2017). Am J Pathol, 187(12):2895-2911.
  • Redmann, M., Benavides, G.A., Berryhill, T.F., Wani, W.Y., Ouyang, X., Johnson, M.S., Ravi, S., Barnes, S., Darley-Usmar, V.M., Zhang, J. Inhibition of autophagy with baflomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons. (2017). Redox Biol, 11:73-81.
  • Chacko, B.K., Wall, S.B., Kramer, P.A., Ravi, S., Mitchell, T., Johnson, M.S., Wilson, L., Barnes, S., Landar, A., Darley-Usmar, V.M. Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils. (2016). Redox Biol, 9:57-66.
  • Slatter, D.A., Aldrovandi, M., O’Connor, A., Allen, S., Brasher, C., Murphy, R.C., Mecklemann, S., Ravi, S., Darley-Usmar, V. and O’Donnell, V.B. Mapping the human platelet lipidome reveals a wealth of novel species, and reveals cytosolic phospholipase A2 as a regulator of mitochondrial bioenergetics. Cell Metabolism, 23(5):930-44.
  • Ravi, S., Johnson, M.S., Chacko, B., Kramer, P.A., Sawada. H., Locy, M.L., Wilson, L.S., Barnes, S., Marques, M.M., Darley-Usmar, V.M. Defining the bioenergetics of the platelet storage lesion. Modification of platelet proteins by 4-hydroxynonenal: Potential Mechanisms for inhibition of aggregation and metabolism. (2016). Free Radic Biol Med, 91:143-53.
  • Ravi, S., Chacko, B., Kramer, P.A., Sawada. H., Johnson, M.S., Zhi, D., Marques, M.M., Darley-Usmar, V.M. Defining the effects of storage on platelet bioenergetics: The role of increased proton leak. (2015). Biochim Biophys Acta, 1852(11):2525-34.
  • Bernard, K., Logsdon, N.J., Ravi, S., Xie, N., Persons, B.P., Rangarajan, S., Zimjewski, J.W., Mitra, K., Liu, G., Darley-Usmar, V.M. and Thannickal, V.J. Metabolic Reprogramming is Required for Myofibroblast Contractility and Differentiation. (2015). The Journal of Biological Chemistry, 290(42):25427-38.
  • Kramer, P. A., Prichard, L., Chacko, B., Ravi, S., Overton, E.T., Heath, S. and Darley-Usmar, V.M. Inhibition of the lymphocyte metabolic switch by the neutrophil oxidative burst. (2015). Clinical Science. 129(6):489-504.
  • Ravi, S., Chacko, B., Sawada, H., Kramer, P.A., Johnson, M.S., Benavides, G.A., O’Donnell, V., Marques, M.B. and Darley-Usmar, V.M. Metabolic Plasticity in Resting and Thrombin Activated Platelets. (2015). Plos One, 10(4):e0123597.
  • Hu, S., Danilov, A.V., Godek, K., Orr, B., Tafe, L.J., Rodriguez-Canales, J., Behrens, C., Mino, B., Moran, C.A., Memoli, V.A., Mustachio, L.M., Galimberti, F., Ravi, S., DeCastro, A., Lu, Y., Sekula, D., Andrew. A.S., Wistuba, I.I., Freemantle, S., Compton, D.A., Dmitrovsky, E. CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110. (2015). Cancer Research, 75(10):2029-38
  • Jiang, S, Park D.W., Gao, Y., Ravi, S., Darley-Usmar, V.M., Edward Abraham, E., and Zmijewski, J.W. Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase. (2015). Cellular Signaling, 27(6):1186-97
  • Kramer, P.A., Chacko, B., Ravi, S., Johnson, M.S., Mitchell, T., Barnes, S., Arabshahi, A., Dell'italia, L., George, D., Steele, C., George, J., Darley-Usmar, V.M. and Melby, S. Hemoglobin-associated Oxidative Stress in the Pericardial Compartment of Post-operative Cardiac Surgery Patients. (2015). Laboratory Investigation, 95(2):132-41.
  • Giordano, S., Dodson, M., Ravi, S., Redmann, M., Ouyang, X., Darley-Usmar, V.M., Zhang, J. Bioenergetic adaptation in response to autophagy regulators during rotenone exposure. (2014). Journal of Neurochemistry, 131(5): 625-33.
  • Chacko, B.K., Kramer, P.A., Ravi, S., Benavides, G.A., Mitchell, T., Dranka, B.P., Ferrick, D., Singla, A.S., Ballinger, S.W., Bailey, S.M, Hardy, R.W., Zhang, J, Zhi, D, Darley-Usmar, V.M. The Bioenergetic Health Index: a new concept in mitochondrial translational research. (2014). Clinical Science, 127:367-373.
  • Ravi, S.*, Mitchell, T.*, Kramer, P.A., Chacko, B. and Darley-Usmar, V.M. Mitochondria in Monocytes and Macrophages-Implications for Translational and Basic Research. (2014). International Journal of Biochemistry and Cell Biology. 53: 202-207.*Authors contributed equally to the work.
  • Kramer, P.A., Chacko, B.K., Ravi, S., Johnson, M.S., Mitchell, T, Darley-Usmar, V.M. Bioenergetics and the oxidative burst: protocols for the isolation and evaluation of human leukocytes and platelets. (2014). Journal of Visualized Experiments, (85).
  • Kramer, P.A.*, Ravi, S.*, Chacko, B.K., Johnson, M.S., Darley-Usmar, V.M. A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as   bioenergetic biomarkers. (2014). Redox Biology, 2:206-210.*Authors contributed equally to the work.
  • Jiang, S, Park, D.W., Stigler, W.S., Creighton, J., Ravi, S., Darley-Usmar V.M., Zmijewski, J.W. (2013). Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis. Journal of  Biological Chemistry, 288(36):26013-26.
  • Chacko, B.K., Kramer, P.A., Ravi, S., Johnson, M.S., Hardy, R.W., Ballinger, S.W., Darley-Usmar, V.M. Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood. (2013). Laboratory Investigation, 93(6):690-700.
  • Mollmark, J.I. *, Ravi, S. *, Sun, B., Shipman, S., Buitendijk, M., Simons, M., and Mulligan-Kehoe, MJ. The anti-angiogenic activity of rPAI-123 promotes vasa vasorum regression in atherogenic mice through a plasmin-dependent mechanism. (2011). Circulation Research, 108(12):1419-28. *Authors contributed equally to the work.
  • Kim, C., Srivastava, S., Rice, M., Godenschwege, T.A., Bentley, B., Ravi, S., Shao, S., Woodard, C., and Schwartz, L.M. (2011). Expression of human amyloid precursor protein in the skeletal muscles of Drosophila results in age- and activity-dependent muscle weakness. BMC Physiology, 11(1):7.
  • Galimberti, F., Thompson, S.L., Ravi, S., Compton, D.A., and Dmitrovsky, E. Anaphase catastrophe is target for cancer therapy. (2011). Clinical Cancer Research, 17(6):1218-22. Wang, L., Ellsworth, K.A., Moon, I., Pelleymounter, L.L., Eckloff, B.W., Martin, Y.N., Fridley, B.L.,  Jenkins, G.D., Batzler, A., Suman, V.J., Ravi, S., Dixon, J.M., Miller, W.R., Wieben, E.D., Buzdar, A., Weinshilboum, R.M., Ingle, J.N. (2010). Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors. Cancer Research, 70(1):319-28.

Invited oral presentations

  • Experimental Biology, April 2nd-6th 2016, San Diego, CA
  • XG Users’ Group Meeting, March 2nd-4th 2015, Birmingham, AL
  • Gordon Research Conference on Oxygen Radicals, February 9th-14th 2014, Ventura, CA