Matthew M. Draelos

Dr. Matthew Draelos

First Year Resident

Start Year


What are your career interests?

Transdermal drug delivery systems, minimally-invasive diagnostic methodologies, wound healing, cutaneous fungal infections, and metabolomics

Why did you choose Duke for residency training?

Duke University has a strong tradition of interdisciplinary research, which is critical for addressing outstanding treatment challenges in dermatology. Duke also has world-class facilities to support transformative and translational research. Duke is a highly collegial environment and offers a well-rounded and diverse dermatology program with training experiences within a tertiary and quaternary care facility, outlying clinics, and the Durham VA.

Education & Training

Undergraduate:  North Carolina State University (NCSU), Chemistry with Honors, Biochemistry with Honors, BS, 2014

Medical School: Duke University Medical Center, MD, 2022

Internship: Internal Medicine, University of North Carolina, Chapel Hill Medical Center, 2022-2023

Residency: Dermatology, Duke University Medical Center, 2023-2027

Graduate School: Duke University Graduate School, Chemistry, PhD, 2022 

Awards & Honors

  • University of North Carolina, Chapel Hill Medical Center Outstanding Preliminary Resident; 2023
  • Duke Graduate School Chemistry Department Peter W. Jeffs Fellowship; 2020
  • Duke University Biochemistry Department Symposium Best Poster Award; 2019                                    
  • Duke University Biochemistry Department Symposium Best Poster Award; 2018
  • Duke University Scholars in Molecular Medicine; 2018
  • NCSU Valedictorian; 2014                                                      
  • NIH Medical Scientist Training Program Fellowship, Duke University; 2014
  • National Science Foundation Graduate Research Fellowship, Chemistry; 2014
  • NCSU Chemistry Department Outstanding Student Award; 2014
  • NCSU Chemistry Department Undergraduate Research Award; 2014
  • NC Biotechnology Undergraduate Research Fellowship; 2013                                               
  • F. Ivy Carroll NC-ACS Undergraduate Scholarship Award; 2013      
  • NCSU Phi Beta Kappa; 2012
  • NCSU Golden Chain Society Member; 2012
  • Amgen Scholar, University of California, Berkeley; 2011
  • NCSU Undergraduate Research Grant; 2011                                                                                
  • NCSU Park Undergraduate Research Grant; 2011
  • Phi Kappa Phi; 2011                                                            
  • NCSU Park Scholar; 2010

Publications & Presentations

Original Publications

Draelos, MM; Thanapipatsiri, A; Du, Y; and Yokoyama, K. “Cryptic Phosphorylation-Mediated Divergent Biosynthesis of High-Carbon Sugar Nucleoside Antifungals.” ACS Chemical Biology. 2022. 14(4), 898-907.

Draelos, ZD and Draelos, MM. “Development of a tape-stripping/LC-MS method for evaluating deposition of topical tazarotene in skin.” Journal of Drugs in Dermatology. 2021. 20(10), 1105-1111.

Draelos, MM; Thanapipatsiri, A; and Yokoyama, K. “2’-OH phosphorylation aids substrate recognition in the amide ligation of peptidyl nucleosides.” Biochemistry. 2021. 60(28), 2231-2235.

Draelos, MM; Thanapipatsiri, A; Sucipto, H; and Yokoyama, K. “Cryptic phosphorylation in nucleoside natural product biosynthesis.” Nature Chemical Biology. 2021. doi: 10.1038/s41589-020-00656-8.

Draelos, MM; Yokoyama, K. “Biosynthesis and Mechanism of Action of Antifungal Peptidyl Nucleoside Natural Products” in Comprehensive Natural Products III: Chemistry and Biology, Volume II. Elsevier, New York. 2019.

Williams, JC; Imlay, HD; Sheldon, JR; Dutter, BF; Draelos, MM; Skaar, EP; Sulikowski, GA. “Synthesis of the siderophore coelichelin and its utility as a probe in the study of bacterial metal sensing and response.” Organic Letters. 2019, 21, 679-682.

Koryakina I; McArthur JB; Draelos, MM; Randall S; Muddiman D; Williams GJ. “Reprogramming the biosynthesis of natural products by directed evolution.” Developments in Biotechnology and Bioprocessing, 2013, 9, 147-63.

Koryakina, I; McArthur, JB; Draelos, MM; Williams, GJ. “Promiscuity of a modular polyketide synthase towards natural and non-natural extender units.” Organic & Biomolecular Chemistry. 2013, 11(27), 4449-58.

Koryakina, I; McArthur, J; Randall, S; Draelos, MM; Musiol, EM; Muddiman, DC; Weber, T; Williams, GJ. “Poly Specific trans-Acyltransferase Machinery Revealed via Engineered Acyl-CoA Synthetases.” ACS Chemical Biology. 2013, 8(1), 200-8.

Draelos, MM and Draelos, ZD. “The biofilm, injectables, and cosmetic dermatology.” Journal of Cosmetic Dermatology. 2013.  12, 245-246.

Draelos, M and Draelos, ZD. “Multicultural Perceptions of Facial Skin Color Abnormalities.” Cosmetic Dermatology. 2010. 23(1), 13-16.

Selected Presentations

Poster Presentation. Draelos, ZD; Draelos, MM; and Praestegaard, M. “Enhanced Skin Deposition of Betamethasone Dipropionate into the Skin of Human Volunteers from Calcipotriene/Betamethasone Dipropionate Cream Compared to Topical Suspension.” SKIN The Journal of Cutaneous Medicine. 2022. 6(6), S54.

Oral Poster Presentation, Society for Investigative Dermatology, 2021 Virtual Meeting, Development of a tape-stripping/LC-MS method for evaluating deposition of topical tazarotene in skin.

Poster Presentation. National American Chemistry Society 2021 Virtual Meeting, Peptidyl nucleoside natural product biosynthesis proceeds through cryptic 2’ phosphorylation.

Poster Presentation. Duke University, Durham, NC, Mechanistic studies of oxidative C-C bond cleaving enzymes in antifungal nucleoside biosynthesis. 2021.

Oral Presentation. Duke University Biochemistry Seminar, Durham, NC, Cryptic phosphorylation in nucleoside natural product biosynthesis. 2020.

Poster Presentation. Duke University Biochemistry Symposium, Durham, NC, Discovery of cryptic phosphorylation reveals the mechanism of antifungal nucleoside biosynthesis. 2019

Poster Presentation. Duke University Biochemistry Symposium, Durham, NC, Characterization of the PLP-dependent enzyme NikK in the biosynthesis of the unusual nucleoside of nikkomycins. 2018

Poster Presentation. Duke University MSTP Symposium, Durham, NC, Elucidation of key steps in nikkomycin biosynthesis for the bio-combinatorial synthesis of novel antifungals. 2018

Poster Presentation. NCSU Undergraduate Research Symposium, Raleigh NC, Improving the efficiency of polyketide synthase high-throughput screens. 2014